Yoshitaka Taketomi Selected Research

Secretory Phospholipases A2

1/2022	Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.
1/2020	Group V secreted phospholipase A2 plays a protective role against aortic dissection.
1/2018	Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics.
3/2016	Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.
1/2016	Metabolic regulation by secreted phospholipase A2.
1/2016	Expression and Function of Group IIE Phospholipase A2 in Mouse Skin.
1/2016	Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.
10/2015	The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
5/2015	Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer.
1/2015	Secreted phospholipase A2 and mast cells.

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Yoshitaka Taketomi Research Topics

Disease

21	Inflammation (Inflammations) 04/2022 - 11/2006
8	Neoplasms (Cancer) 04/2022 - 12/2011
8	Anaphylaxis (Anaphylactic Shock) 11/2017 - 06/2007
6	Atherosclerosis 01/2016 - 11/2008
4	Hypersensitivity (Allergy) 04/2022 - 10/2011
4	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022 - 01/2016
3	Obesity 01/2020 - 07/2014
3	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 02/2013
2	Carcinogenesis 01/2022 - 05/2015
2	Fibrosis (Cirrhosis) 01/2022 - 10/2020
2	Skin Diseases (Skin Disease) 01/2022 - 01/2018
2	Contact Dermatitis (Eczema, Contact) 01/2021 - 06/2013
2	Insulin Resistance 10/2020 - 01/2016
2	Hyperplasia 01/2018 - 10/2015
2	Colitis 01/2017 - 03/2016
2	Asthma (Bronchial Asthma) 12/2011 - 06/2010
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Metabolically Benign Obesity 10/2020
1	Osteoarthritis 04/2020
1	Rheumatoid Arthritis 04/2020
1	Aortic Dissection 01/2020
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Lung Injury 10/2016
1	Acute Lung Injury 10/2016
1	Lymphopenia (Lymphocytopenia) 03/2016
1	Skin Neoplasms (Skin Cancer) 01/2016
1	Disease Progression 03/2015
1	Pathologic Neovascularization 03/2015
1	Edema (Dropsy) 02/2014
1	Neoplasm Metastasis (Metastasis) 02/2013
1	Atherosclerotic Plaque (Atheroma) 12/2011
1	Allergic Rhinitis 12/2011
1	Atopic Dermatitis (Atopic Eczema) 12/2011

Drug/Important Bio-Agent (IBA)

17	Secretory Phospholipases A2IBA 01/2022 - 11/2008
15	LipidsIBA 01/2022 - 06/2013
7	EnzymesIBA 01/2020 - 11/2008
6	Phospholipases A2 (Phospholipase A2)IBA 01/2022 - 06/2013
5	CytokinesIBA 03/2016 - 06/2009
5	Group X Phospholipases A2IBA 03/2016 - 11/2006
4	Phospholipases (Phospholipase)IBA 07/2014 - 10/2010
3	Proteins (Proteins, Gene)FDA Link 04/2022 - 05/2015
3	Immunoglobulin E (IgE)IBA 01/2021 - 06/2007
3	ProstaglandinsIBA 10/2020 - 10/2010
3	Arachidonic Acid (Vitamin F)IBA 04/2020 - 10/2011
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020 - 04/2011
3	EicosanoidsIBA 11/2017 - 11/2006
3	Dinoprostone (PGE2)FDA Link 03/2016 - 06/2009
2	Insulin (Novolin)FDA Link 10/2020 - 04/2011
2	LeukotrienesIBA 04/2020 - 10/2016
2	Fatty Acids (Saturated Fatty Acids)IBA 04/2020 - 03/2016
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2020 - 03/2016
2	Dextran SulfateIBA 01/2017 - 03/2016
2	Group II Phospholipases A2IBA 01/2016 - 06/2013
2	Biological ProductsIBA 01/2016 - 06/2010
2	CalpainIBA 03/2015 - 12/2011
2	AMP-Activated Protein KinasesIBA 09/2014 - 09/2013
2	ChemokinesIBA 01/2014 - 06/2009
2	Lipoproteins (Lipoprotein)IBA 06/2011 - 11/2008
1	phosphatidylethanolamineIBA 01/2022
1	Imiquimod (Aldara)FDA LinkGeneric 01/2022
1	N-acylethanolaminesIBA 01/2022
1	Irritants (Vesicants)IBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 04/2020
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2020
1	protectin D1IBA 04/2020
1	Lipoxygenase (Lipoxygenase-1)IBA 04/2020
1	LipoxinsIBA 04/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Linoleic Acid (Linoleate)IBA 01/2020
1	Angiotensin IIIBA 01/2020
1	Epoxy Compounds (Epoxides)IBA 11/2017
1	Leukotriene B4IBA 10/2016
1	Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA 10/2016
1	Streptococcus pneumoniae plY proteinIBA 10/2016
1	AcidsIBA 10/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2016
1	Sterol Regulatory Element Binding Protein 1IBA 06/2015
1	Transcription Factors (Transcription Factor)IBA 06/2015
1	calpastatinIBA 03/2015
1	Oxygen (Dioxygen)IBA 03/2015
1	Interleukin-6 (Interleukin 6)IBA 03/2015
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015
1	Vascular Endothelial Growth Factor CIBA 03/2015
1	Janus KinasesIBA 03/2015
1	Neutralizing AntibodiesIBA 03/2015
1	U 0126 (UO 126)IBA 09/2014
1	Lipase (Acid Lipase)FDA Link 07/2014
1	AntigensIBA 01/2014
1	Bee Venoms (Bee Venom)IBA 01/2014
1	Prostaglandin D2IBA 01/2014
1	AICA ribonucleotide (ZMP)IBA 09/2013
1	HaptensIBA 06/2013
1	cadherin 5IBA 12/2011
1	m-calpainIBA 12/2011
1	Cysteine Proteases (Cysteine Protease)IBA 12/2011
1	Plant ExtractsIBA 12/2011
1	Anti-Allergic Agents (Antiallergic Agents)IBA 12/2011
1	Emodin (Archin)IBA 12/2011

Therapy/Procedure

2	Therapeutics 01/2018 - 10/2016